Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome
نویسندگان
چکیده
منابع مشابه
Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome
OBJECTIVE Quantitative Structure-Activity Relationship (QSAR) models can predict adverse drug reactions (ADRs), and thus provide early warnings of potential hazards. Timely identification of potential safety concerns could protect patients and aid early diagnosis of ADRs among the exposed. Our objective was to determine whether global spontaneous reporting patterns might allow chemical substruc...
متن کاملStevens-Johnson Syndrome
A 13-year-old boy was brought to the emergency department (ED) with a generalized itchy rash of 2 days' duration. For the past 3 days, he had dry, itchy eyes with a purulent discharge (Figure 1) and nonbilious emesis 2 or 3 times per day, with some blood streaks in the vomitus on the third day of illness. Chills developed on the third day, but the patient's temperature was not measured. His lip...
متن کاملStevens-Johnson Syndrome
Figure 1. Anteroposterior view of the trunk with coa-lescing vesicobullous lesions.
متن کاملStevens-Johnson syndrome due to strontium ranelate.
systemic steroids – initially intravenous hydrocortisone 100 mg 8-hourly for 3 days, followed by oral prednisolone 50 mg a day – as well as topical triamcinolone oral paste and an antiseptic mouthwash. She responded well to treatment. Strontium ranelate is a relatively new medication for the treatment of post-menopausal osteoporosis. It simultaneously increases bone formation and decreases bone...
متن کاملStevens-Johnson syndrome after sertraline.
Sir, Sertraline (Zoloft1) is a new selective inhibitor of serotonin re-uptake. This family of antidepressant drugs is considered to be safe, and cutaneous adverse reactions have rarely been reported (1). We report here a patient who developed StevensJohnson syndrome (SJS) after starting treatment with sertraline (Zoloft1). A 96-year-old woman was admitted with a cutaneous and mucosal eruption. ...
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ژورنال
عنوان ژورنال: Journal of the American Medical Informatics Association
سال: 2015
ISSN: 1527-974X
DOI: 10.1093/jamia/ocv127